The objective of the article is to review the microsphere based technologies and their recent advances in floating drug delivery systems. Floating drug delivery systems are designed for poorly soluble, unstable and locally acting drugs in the gastrointestinal tract. They bear lower bulk density than gastric content and thus float in the stomach for a prolonged period of time. Designing of floating microspheres is one of the approaches in delivering a drug in controlled release pattern, to achieve plasma concentration rendering better therapeutically efficacy via improved biopharmaceutical characteristics of the drug. This review provides advancements in microsphere based floating drug delivery systems (FDDS) with different categories of drugs addressing related critical issues.
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